Advancements in Science & Tech
What are Exosomes?
Exosomes act as cellular messengers, orchestrating vital communication and RNA/protein exchange among cells like fibroblasts, keratinocytes, and immune cells.
They ferry an array of growth factors, cytokines, and genetic materials, showcasing promising abilities in tissue repair and enhancing skin cell vitality.
Harnessing these data-encoded avatars, our innovative line of exosome products aims to unveil a luminous, age-defying complexion.
Why BENEV Exosomes?
POWERED BY EXOSCRT™
Exosomes, ranging in size from 30 to 200 nm, are secreted from the endoplasmic reticulum and are crucial for cell-to-cell communication, significantly impacting the cellular microenvironment. ExoSCRT™ represents a groundbreaking technology that isolates and purifies exosomes with 0.1 to 0.5% purity from stem cells. This technology effectively enhances the natural energy of the skin by interacting beneficially with skin cells.
Human Fibroblast Cell Proliferation
BENEV Exosome products, utilizing the advanced ExoSCRT™ technology, significantly boost skin cell proliferation in a dose-dependent fashion. When tested, ExoSCRT™ at 3 µg/ml resulted in a 36.1% increase, while at 6 µg/ml, it achieved an impressive 84.0% increase, both compared to the positive control (1% GS).
Human Fibroblast Cell Growth Enhancement
BENEV Exosome products, driven by ExoSCRT™ technology, have the potential to boost elastin levels in human dermal fibroblasts by up to 300% in vitro.
Collagen Boosted by ExoSCRT™
Following the introduction of BENEV Exosome products enhanced by ExoSCRT™ into fibroblasts, neocollagenesis can surge up to sixfold.
Cellular Internalization of Exosomes via ExoSCRT™
Human skin cells readily absorb BENEV products enhanced with ExoSCRT™ technology, allowing stem cell-derived exosomes to effectively communicate with skin cells and trigger specific actions.
IN VIVO ANALYSIS
Exosomes, nano-sized vesicles ranging from 30 to 200 nm, are continuously released by nearly all cells. Their capability to traverse cellular boundaries and deliver lipids, proteins, and nucleic acids makes them a promising cell-free therapeutic option for various diseases.
In this study, we explored for the first time whether exosomes derived from human adipose tissue mesenchymal stem cells can alleviate atopic dermatitis (AD) in an in vivo mouse model.
When administered either intravenously (IV) or subcutaneously (SC) to NC/Nga mice treated with house dust mite antigens, ERC-exosomes significantly reduced pathological symptoms, including clinical scores, serum IgE levels, blood eosinophil counts, and the infiltration of mast cells, CD86+, and CD206+ cells in skin lesions. Additionally, ERC-exosomes markedly decreased mRNA expression of inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor-alpha (TNF-α) in AD skin lesions of Nc/Nga mice. These findings indicate that ERC-exosomes could be a novel, promising cell-free therapeutic modality for treating AD.
(Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha, and Yong Weon – Stem Cell Research Therapy, BioMedCentral.com)
Disclaimer:
For United States customers only.
BENEV Exosome Products are intended for post-care “topical use” as cosmetic solutions. The isolated and purified exosomes in these products have been approved by the Personal Care Products Council (PCPC) and the International Cosmetic Ingredient Nomenclature Committee (INC). The designation ‘Human Adipose Stromal Cell Exosomes’ has been officially published in the International Cosmetic Ingredient Dictionary and Handbook, also known as the INCI book. Currently, no other cosmetic INCI names have been assigned to exosome products on the market prior to this achievement. These products are not drugs and are not designed to prevent, treat, or cure any diseases or medical conditions. They are not intended for injection or intravenous delivery.
Professional Use
ERC
Exosome Regenerative Complex
The Exosome Regenerative Complex is an advanced, clinically validated, dual-action formulation designed to revitalize and restore the skin’s youthful appearance.
Professional Use
ERC+
Exosome Regenerative Complex+
Exosome Regenerative Complex+ is an exceptionally powerful and potent dual-action formulation designed to rejuvenate and regenerate both skin and scalp, delivering noticeable results in a remarkably short time.
Home-Care Use
EXO BALM
Exosome Post-Treatment Enhancing Balm
A blend of exosomes and intensive hydrators to maximize treatment outcomes, minimize inflammation, and shorten recovery time.
Home-Care Use
MASK
Exosome Soothing Gel Mask
Our potent hydrating essence gel mask is meticulously crafted to calm, soothe, and deeply hydrate, rebalancing the skin’s moisture barrier at the cellular level to restore a youthful, radiant complexion.
RF Microneedling Renaissance
Pioneering a Novel Approach to Skin Rejuvenation
Clinical Results
BEFORE & AFTERS
Patient trial photos (Mei Vu™) were captured before and after a 3 to 5 session Clinical Study showcasing the BENEV Exosome Regenerative Complex powered by ExoSCRT™. Participants experienced no irritation and unanimously reported a visible and immediate improvement in their skin’s overall appearance after just one treatment, with complete results evident after the third to fifth sessions.
